Camptothecin prodrug

WebSep 20, 2024 · The construction of prodrug and glucose oxidase coloaded alginate (ALG) hydrogels for PDT-combined chemotherapy of melanoma will provide a promising injectable hydrogel platform for effective treatments of cancer. Biomimetic nanoprodrugs from fatty acid modified camptothecin and albumin for enhanced pharmacotherapy. WebFeb 16, 2024 · The aim of this study was to prepare small-molecule camptothecin (CPT) prodrugs and evaluate their effectiveness in colorectal carcinoma therapy. Prodrug nanoparticles (NPs) were physicochemically characterized and evaluated for their cytotoxicity in human colon cancer (HCT116) cell lines. The antitumor efficacy of the NPs …

ROS‐Responsive Camptothecin Prodrug ... - Wiley Online …

WebSep 18, 2024 · Methotrexate–Camptothecin Prodrug Nanoassemblies as a Versatile Nanoplatform for Biomodal Imaging-Guided Self-Active Targeted and Synergistic Chemotherapy ACS Applied Materials & Interfaces ACS ACS Publications C&EN CAS Find my institution Log In Share Share on Facebook Twitter WeChat Linked In Reddit Email … WebCamptothecin and lactose act as the chemotherapy drug and targeting ligand in the drug delivery system, respectively. Since CPT-S-S-LA is an amphiphilic compound, it can self-assemble into nanoparticles with a diameter of around 110 nm. The CPT-S-S-LA nanoparticles displayed controllable drug release behavior in the physiological environment. church house grazeley https://shadowtranz.com

Development of a Prodrug of Camptothecin for Enhanced ... - PubMed

WebNov 28, 2024 · Camptothecin (CPT), a DNA topoisomerase I inhibitor that induces DNA damage in cancer cells, has been widely used for the treatment of a variety of cancers, … WebDec 1, 2024 · Self-assembled prodrugs (SAPDs), which combine prodrug strategy and the merits of self-assembly, not only represent an appealing type of therapeutics, enabling the spontaneous organization of supramolecular nanocomposites with defined structures in aqueous environments, but also provide a new method to formulate existing drugs for … WebJan 13, 2024 · Therapeutic conjugate approaches that alter the solubility of a conjugate “prodrug” have been used to enable NC formation and controlled release from NCs using labile linker chemistry. A limitation of this approach has been that a different linker chemistry must be used to produce an adjustable release rate for a single therapeutic. church house godalming

A GSH-Responsive Nanoprodrug System Based on Self-Assembly …

Category:A GSH-Responsive Nanoprodrug System Based on Self …

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Camptothecin prodrug

Methotrexate–Camptothecin Prodrug Nanoassemblies as a …

WebDOI号:文献链接:文献作者:备注信息: Camptothecin-doxorubicin prodrug and its preparation method and application WebGlucuronide camptothecin is a type of prodrug produced from camptothecin and glucuronide. Glucuronide, which is also referred to as glucuronoside, is substance produced by linking glucuronic acid to another substance via a glycosidic bond. The prodrug could catalyze and produce the drug camptothecin (CPT), which was discovered in 1966.

Camptothecin prodrug

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WebDec 1, 2024 · To increase drug loading and combination therapy, we covalently conjugated paclitaxel (PTX) and camptothecin (CPT) through a disulfide linker into a prodrug, designated PTX-S-S-CPT. The... WebApr 23, 2024 · Herein, a helix self-assembly camptothecin (CPT) prodrug with simultaneous physical and physiological tumor penetration was constructed to realize effective chemo-immunotherapy. Specifically, CPT was modified with arginine to self-assemble into nanofibers to physically improve tumor penetration.

WebKeywords: CPT prodrug, dual responsive, sequential drug release, prostate-specific membrane antigen, ... Li Y, Lin J, Ma J, et al. Methotrexate–camptothecin prodrug nanoassemblies as a versatile nanoplatform for biomodal imaging-guided self-active targeted and synergistic chemotherapy. WebNational Center for Biotechnology Information

WebThe clinical efficacy of cytotoxic drugs in the treatment of cancer is often hampered by poor pharmacodynamics and systemic toxicity. Here, we describe the design and synthesis of a new PEG-based system for the delivery of the cytotoxic camptothecin (CPT) into tumor cells that overexpress luteinizing hormone releasing hormone receptor (LHRHR). WebHerein, we fabricated a novel amphiphilic lactose-camptothecin prodrug molecular Lac-SS-CPT which can self-assemble into Lac-SS-CPT glyco-nano prodrug system for GSH responsive and targeted drug co-delivery due to the existence of disulfide bond and lactose. 41–44 Then, the CPT-based glyco-nano prodrug system further provides a suitable ...

WebEster prodrugs are most often used to enhance the lipophilicity, and thus the passive membrane permeability, of water-soluble drugs by masking charged groups such as carboxylic acids and...

WebFeb 28, 2024 · Camptothecin (CPT) is a pentacyclic quinoline alkaloid drug, which possesses superior antitumor efficacy, antiproliferative effect and apoptosis induction capacity in colon, lung, breast, ovarian, melanoma and other cancers. church house greave foldWebA novel amphiphilic camptothecin prodrug that spontaneously arranges into nanomicelles which preferentially release the cytotoxic drug under tumor-relevant reductive conditions is designed. You have access to this article devils panthersWebA novel functional reducible camptothecin (CPT) block copolymer conjugate was prepared using atom transfer radical polymerization (ATRP). The use of ATRP in the design and … devil spanishWebJan 23, 2024 · Bio-(8)-MB-CPT thus exerted strong toxicity towards cervical cancer cells, but unlike the parent drug (camptothecin), showed no toxicity towards normal cells. Moreover, the prodrug displayed significantly enhanced antitumor efficacy in vivo and eradicated the tumor with no obvious side effects (inhibition of the tumor reached up to 99.9 %). church house great elmWebOct 21, 2024 · A camptothecin prodrug induces mitochondria-mediated apoptosis in cancer cells with cascade activations. Mitochondria are crucial regulators of the … church house guildford dioceseNational Center for Biotechnology Information church house great harwoodWebSep 20, 2024 · Minimizing drug leakage in systemic circulation, synchronizing the in vivo fate of multiple drugs, and precisely controlling tumor locoregional drug release, remain … devils panthers game