Kabachnik–fields reaction
WebbKabachnik–Fields反应（Kabachnik–Fields reaction），由 Martin Izrailevich Kabachnik和 Ellis K. Fields 分别在1952年发现。 一分子羰基化合物、一分子胺与一分子膦酸二酯多 … Webb11 mars 2024 · Kabachnik–Fields reaction of benzhydrylamine, 9-anthraldehyde and dialkyl phosphites. 9-Anthraldehyde proved to be a somewhat more hindered model in Kabachnik–Fields reaction with benzhydrylamine and dialkyl phosphites, as only lower proportions of the corresponding α-aminophosphonates (8a–c) could be obtained.
Kabachnik–fields reaction
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The reaction is very similar to the two-component Pudovik reaction, which involves condensation of the phosphite and a preformed imine. The first step in this reaction is the formation of an imine, followed by a hydrophosphonylation step where the phosphonate P-H bond across the C=N double bond. Webb25 apr. 2024 · In this paper, the microwave (MW)-assisted catalyst-free and mostly solvent-free Kabachnik-Fields reaction of amino alcohols, paraformaldehyde, and various >P(O)H reagents (dialkyl phosphites, ethyl phenyl-H-phosphinate, and secondary phosphine oxides) is reported.The synthesis of N-2-hydroxyethyl-α-aminophosphonate …
Webb16 feb. 2007 · Commercially available magnesium perchlorate is reported as an extremely efficient catalyst for the synthesis of alpha-aminophosphonates. A three-component … WebbKabachnik–Field reaction by examining aromatic aldehydes since it was the expectation that reaction optimization would not be as challenging. We had previously reported a …
Webb18 jan. 2024 · This research exploits a biocompatible magnetic self-healing hydrogel with well-dispersed IONPs, demonstrating the value of the KF reaction in the development of functional polymers and smart materials, which might prompt a broad study of multicomponent reactions in interdisciplinary fields. Research Support, Non-U.S. Gov't. WebbThe review discusses recent achievements in the development of more ecofriendly and economically viable processes for the synthesis of biologically potent α …
Webb1 apr. 1996 · The Kabachnik–Fields reaction: synthetic potential and the problem of the mechanism. R. Cherkasov, V. Galkin; Chemistry. 1998; The published data of the last decade concerning the mechanism of the Kabachnik–Fields reaction and its significance for the chemistry of organophosphorus compounds as a method for the synthesis of …
Webbinductions in the Kabachnik–Fields reaction for a variety of aryl aldehydes.16 This reaction is unusual in that, instead of a phosphite diester, a phosphite triester was employed in this Kabachnik–Fields reaction where one of the ethyl groups was cleaved during the reaction to give the phophonate diester 27. headset for polycom phoneWebb16 feb. 2007 · Commercially available magnesium perchlorate is reported as an extremely efficient catalyst for the synthesis of alpha-aminophosphonates. A three-component reaction (3-CR) of an amine, an aldehyde or a ketone, and a di-/trialkyl phosphite (Kabachnik-Fields reaction) took place in one pot under solvent-free conditions to … headset for polycom hd voice phoneWebb18 jan. 2008 · A Critical Overview of the Kabachnik–Fields Reactions Utilizing Trialkyl Phosphites in Water as the Reaction Medium: A Study of the … gold tipped dining tableWebbAbstract. A simple, efficient and eco-friendly protocol has been described for the synthesis of α-aminophosphonates via Kabachnik-Fields reaction, catalyzed by H 6 P 2 W 18 O 62 ·14H 2 O as a reusable catalyst. The reaction was realized by condensation of amino acids, various aromatic aldehydes and triethylphosphite under solvent-free conditions, … gold tipped bulbsWebbThe Kabachnik-Fields Reaction is very important in drug discovery research for generating peptidomimetic compounds. Early protocols were limited to simple … headset for phone and pcWebb4a obtained in the course of the Kabachnik–Fields reaction (Scheme 1). It is considered of interest to compare the rates of the Kabachnik–Fields and Pudovik reactions on the basis of interactions de-picted in Schemes 1 and 2. It was found that α-aminophosphonates E,Z-4a in the Pudovik reaction formsmoreslowly. The α,β … headset for pc with microphoneWebb5 juli 2024 · Owing to the high degree of atom economy, Kabachnik-Fields reaction (KF-3CR) (Kabachnik and Medved, 1952, Fields, 1952), which is derived from aldehyde, … gold tipped coffee table